VORICLONE is a brand name for voriconazole, a triazole antifungal agent used to treat serious fungal infections. The 75 mL formulation is typically available as an oral suspension, providing a concentration of 40 mg/mL voriconazole. This formulation is intended for patients who cannot take oral tablets or require a liquid form for accurate dosing.
Indications: Voriconazole is indicated for:
Treatment of invasive aspergillosis.
Treatment of candidemia in non-neutropenic patients.
Treatment of serious invasive Candida infections, including those caused by Candida krusei.
Treatment of serious fungal infections caused by Scedosporium spp. and Fusarium spp.
Prophylaxis of invasive fungal infections in patients aged 12 years and older who are at high risk.
Dosage and Administration: The dosing regimen for voriconazole varies based on the severity of the infection and the patient's age and weight. For adults with invasive aspergillosis, the recommended initial dose is 6 mg/kg every 12 hours for the first 24 hours, followed by 4 mg/kg every 12 hours. For pediatric patients, dosing is typically based on body weight. It's essential to follow the prescribing information specific to the formulation and consult a healthcare professional for personalized dosing. citeturn0search2
Administration: Voriconazole oral suspension should be taken on an empty stomach, at least 1 hour before or 1 hour after a meal. The suspension should be shaken well before each use to ensure uniform dosing.
Storage: Store the oral suspension at 2°C to 8°C (36°F to 46°F) before reconstitution. After reconstitution, the suspension should be stored at 15°C to 30°C (59°F to 86°F) and used within 14 days. Do not refrigerate or freeze the reconstituted suspension. citeturn0search1
Precautions:
Voriconazole may cause liver toxicity; monitor liver function tests during therapy.
It can cause visual disturbances, including blurred vision and color vision changes.
Voriconazole is metabolized by the liver; dose adjustments may be necessary in patients with hepatic impairment.
It may interact with other medications; inform your healthcare provider of all concurrent medications.
Side Effects: Common side effects include:
Visual disturbances.
Liver enzyme abnormalities.
Rash.
Nausea and vomiting.
Serious side effects are rare but can include severe liver damage and allergic reactions.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance regarding the use of voriconazole.