Colistin 3 Million IU Injection is an antibiotic used to treat severe bacterial infections caused by multidrug-resistant Gram-negative bacteria. It is particularly effective against pathogens such as Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii. Due to its potential for nephrotoxicity and neurotoxicity, Colistin should be administered under strict medical supervision, typically in a hospital setting.
Composition:
Active Ingredient: Colistimethate sodium equivalent to 3 million international units (IU) of colistin base activity.
Inactive Ingredients: Sodium chloride (for osmolarity adjustment) and water for injection.
Administration:
Route: Intravenous (IV) administration after reconstitution.
Preparation: Reconstitute the powder with the provided diluent as per the manufacturer's instructions. The reconstituted solution should be administered slowly over 30 to 60 minutes.
Storage:
Temperature: Store at controlled room temperature, between 20°C to 25°C (68°F to 77°F).
Conditions: Keep the vial in a cool, dry place, away from direct sunlight and moisture.
Precautions:
Renal Function: Monitor kidney function regularly, as Colistin can cause nephrotoxicity. Dose adjustments may be necessary based on renal function.
Neurological Assessment: Be vigilant for signs of neurotoxicity, such as dizziness, confusion, or seizures.
Allergies: Inform your healthcare provider about any known allergies to antibiotics, especially polymyxins.
Pregnancy and Breastfeeding: Consult your doctor before using this medication if you are pregnant, planning to become pregnant, or breastfeeding.
Side Effects:
Common: Injection site reactions (pain, redness, swelling), fever, rash, and gastrointestinal disturbances (nausea, vomiting).
Serious: Renal toxicity (decreased urine output, swelling), neurotoxicity (dizziness, confusion, seizures), respiratory distress, and apnea.
Important Note:
Colistin should only be used under the supervision of a qualified healthcare professional. Adhere strictly to the prescribed dosage and administration guidelines. Do not self-administer or adjust the dosage without consulting your healthcare provider. Regular monitoring of kidney function and neurological status is essential during treatment.
For more detailed information, please refer to the product's official documentation or consult with a healthcare professional.