Colyclone 2MIU Injection is an antibiotic containing Colistimethate Sodium, which is used to treat serious infections caused by Gram-negative bacteria. Here is the detailed information about the composition and salt:
Composition of Colyclone 2MIU Injection:
Active Ingredient:
Colistimethate Sodium equivalent to 2 million international units (IU) of colistin base activity.
Salt:
Colistimethate Sodium is the salt form of colistin used in the injection. It is a water-soluble form that, when administered, gets converted to colistin, the active antimicrobial agent.
Inactive Ingredients (Excipients):
Sodium Chloride (NaCl) – Used for adjusting the osmolarity of the solution.
Water for Injection – Used as the solvent for reconstituting the powder form into a solution for intravenous use.
Reconstitution:
Colyclone 2MIU comes in a lyophilized powder form, and it needs to be reconstituted with an appropriate diluent (usually water for injection or sodium chloride solution) before intravenous administration.
Once reconstituted, the solution is typically administered intravenously over 30 to 60 minutes.
Dosage:
Colyclone 2MIU is generally administered intravenously, and the exact dosage depends on the infection being treated, the patient's body weight, renal function, and the severity of the infection.
Storage:
Store the vial at controlled room temperature, away from light and moisture.
After reconstitution, the solution should be used immediately or stored as directed by the manufacturer, usually in the refrigerator, depending on the specific guidelines.
Precautions:
Nephrotoxicity: Colistin can cause kidney damage, so it is important to monitor renal function closely during treatment.
Neurotoxicity: Colistin can also cause neurological side effects such as dizziness, confusion, or seizures.
Allergic Reactions: Rare but serious allergic reactions, including anaphylaxis, can occur.
Pregnancy & Breastfeeding: Consult a healthcare provider before using Colistin during pregnancy or breastfeeding.
Side Effects:
Common: Nausea, vomiting, rash, and injection site reactions (pain or swelling).
Serious: Kidney damage (nephrotoxicity), respiratory distress, dizziness, and confusion (neurotoxicity).
Always follow your healthcare provider's instructions and guidelines for the safe use of Colyclone 2MIU Injection.